Modeling Tissue Re-modeling During the Pathogenesis of Abdominal Aortic Aneurysms
نویسندگان
چکیده
منابع مشابه
Modeling the Growth of Infrarenal Abdominal Aortic Aneurysms.
BACKGROUND Abdominal aortic aneurysm (AAA) growth is a complex process that is incompletely understood. Significant heterogeneity in growth trajectories between patients has led to difficulties in accurately modeling aneurysm growth across cohorts of patients. We set out to compare four models of aneurysm growth commonly used in the literature and confirm which best fits the patient data of our...
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Recent studies have shown that increases in proteolytic activity are associated with abdominal aortic aneurysms (AAAs). We have studied samples of the dilated aortic wall, taken during corrective surgery for AAAs, in terms of the number, type, and tissue location of connective tissue proteinases and their inhibitors. Five distinct caseinolytic serine proteinases and six gelatinolytic metallopro...
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The abdominal aortic aneurysm (AAA) is a disease process that carries significant morbidity and mortality in the absence of early identification and treatment. While current management includes surveillance and surgical treatment of low- and high-risk aneurysms, respectively, our narrow understanding of the pathophysiology of AAAs limits our ability to more effectively manage and perhaps even p...
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Introduction At present, the diameter of an abdominal aortic aneurysm (AAA) is considered to be the primary indicator of rupture risk. Surgical treatment is usually performed if the diameter exceeds 5 cm. Rupture does however occur for diameters less than 5 cm. We therefore investigate if better rupture risk indicators can be obtained by patientspecific hemodynamic modeling. This paper discusse...
متن کاملMicromanaging Abdominal Aortic Aneurysms
The contribution of abdominal aortic aneurysm (AAA) disease to human morbidity and mortality has increased in the aging, industrialized world. In response, extraordinary efforts have been launched to determine the molecular and pathophysiological characteristics of the diseased aorta. This work aims to develop novel diagnostic and therapeutic strategies to limit AAA expansion and, ultimately, r...
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ژورنال
عنوان ژورنال: European Journal of Vascular and Endovascular Surgery
سال: 2019
ISSN: 1078-5884
DOI: 10.1016/j.ejvs.2019.06.976